Reteplase Injection

( re′ te plase)

Brand Name(s): Retavase^®

Other Name(s): tPA

WHY is this medicine prescribed?

Reteplase is used to treat a certain type of heart attack to reduce the risk of heart failure and death. Reteplase is in a class of medications called thrombolytic agents.It works by dissolving blood clots and restoring blood flow through the heart.

Are there OTHER USES for this medicine?

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

HOW should this medicine be used?

Reteplase comes as a powder to mix with liquid to inject intravenously (into a vein) by a healthcare provider. It is usually given as soon as possible after the symptoms of a heart attack begin. A second dose is given 30 minutes after the first dose.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What SPECIAL PRECAUTIONS should I follow?

Before receiving reteplase,

• tell your doctor or pharmacist if you are allergic to this drug, any part of this drug, or any otherdrugs, foods or substances. Tell your doctor or pharmacist about the allergy and whatsymptoms you had.

• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take while receiving reteplase. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you recently had a stroke; a serious head injury, or surgery on your spine or brain in the last 3 months; or if you have problems in your brain such as bleeding, a tumor, arteriovenous malformation (AVM), or aneurysm (weakening of a blood vessel wall). Also tell your doctor if you have very high blood pressure that is not controlled by medications or any condition that may cause an increased risk of bleeding or bruising.Your doctor will probably not give you reteplase.

• tell your doctor if you have or have ever had any other medical conditions.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.

What SPECIAL DIETARY instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What SIDE EFFECTS can this medicine cause?

Reteplase may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• bleeding, particularly at the site of injection

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

• rash, itching, redness, swelling of the tongue or throat, dizziness, fainting, and difficulty breathing
• headache, confusion, trouble speaking, weakness or numbness in face, arm or leg (usually on one side)
• skin or toes that are purple in color
• decrease in amount of urine
• changes in vision
• chest pain, trouble breathing
• nausea, vomiting, abdominal pain that goes around your to your back

Reteplase may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to reteplase.

Before having any laboratory test, tell your doctor and the laboratory personnel that you have recently received reteplase.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicinesvitamins, minerals, and dietary supplements you are taking. Bring this list with you each timeyou visit a doctor or if you are admitted to the hospital. You should carry the list with you incase of emergencies.

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. represents that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. makes no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. does not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS^® Patient Medication Information™. © Copyright, 2025. The American Society of Health-System Pharmacists^®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. All Rights Reserved. Duplication for commercial use must be authorized by ASHP.

Selected Revisions: April 15, 2025.